Medicine Recommendations

Opioid-induced constipation

Opioid-induced constipation (NICE TA345)

NICE TA 345 - Naloxegol for treating opioid‑induced constipation

Managing overweight and obesity (NICE TA494)

NICE TA494 - Naltrexone–bupropion for managing overweight and obesity

Acute Gout (as per LSCMMG Guidelines)

MHRA Drug Safety Update - Non-steroidal anti-inflammatory drugs (NSAIDs): reminder on renal failure and impairment

MHRA Drug Safety Update - Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks

MHRA Drug Safety Update - NSAIDs and coxibs: balancing of cardiovascular and gastrointestinal risks

Pain

MHRA Drug Safety Update - Non-steroidal anti-inflammatory drugs (NSAIDs): reminder on renal failure and impairment

MHRA Drug Safety Update - Non-steroidal anti-inflammatory drugs (NSAIDs): cardiovascular risks

MHRA Drug Safety Update - NSAIDs and coxibs: balancing of cardiovascular and gastrointestinal risks

Pain: Anti-inflammatory

Neurogenic bowel dysfunction

Non-neurogenic bowel dysfunction

Treatment of pain

Metabolic acidosis and for maintenance treatment against recurrence of metabolic acidosis in adults with chronic renal impairment.

Prevention and treatment of ischaemia following subarachnoid haemorrhage

Treating COVID-19 (NICE TA878)

NICE TA878 - Nirmatrelvir plus ritonavir, sotrovimab and tocilizumab for treating COVID-19

Insomnia (short term use)

The colour classification was determined as part of the collaborative work between LCFT and medicines Management leads. Local pathways and patient safety were taken into consideration.

Depressive illness

Chronic Neuropathic Pain

Bowel obstruction - GI secretions associated with bowel obstruction. 

Unlicensed use in non-acute treatment of recurrent gastrointestinal bleeding disorders (including angiodysplasia, small bowel dysplasia, gastric antral vascular ectasia, haemorrhagic telangiectasia)

Unlicensed use for orthostatic intolerance disorders e.g. postural orthostatic tachycardia syndrome (PoTS)

Unlicensed use in Secretory Gastrointestinal Disorders (e.g. enterocutaneous fistula, high output stoma and refractory diarrhoea)

Treatment and prophylaxis of schizophrenia