Medicine Recommendations

Crohn's disease, 1st line biologic (NICE TA187) and LSCMMG Recommendation

NICE TA187 - Infliximab and adalimumab for the treatment of Crohn's Disease

First line biologic for moderate to severe active ulcerative colitis after the failure of conventional therapy (NICE TA329) and LSCMMG Recommendation

NICE TA329  Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262)

Crohn's disease, 2nd line biologic (NICE TA187) and LSCMMG Recommendation

NICE TA187 - Infliximab and adalimumab for the treatment of Crohn's Disease

Second line biologic for moderate to severe active ulcerative colitis after the failure of conventional therapy (NICE TA329) and LSCMMG Recommendation

NICE TA329 - Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy

Prevention of recurrence of ulcerative colitis following surgery

Use in high risk patients for prevention of recurrence or upon recurrence of Crohn's Disease following surgery.

Inflammatory bowel disease, Rheumatic diseases, Dermatology

Treatment of mild to moderate ulcerative colitis and maintenance of remission

Constipation in adults

Constipation

For induction of remission in adults with mild to moderate active ulcerative colitis where 5-ASA (aminosalicylate) treatment is not sufficient.

Induction of remission in patients with active microscopic colitis (MC).

For inducing remission of eosinophilic oesophagitis. 

NICE TA 708 - Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitis

Crohn's disease

Ulcerative Colitis

Severe acute ulcerative colitis

Rheumatic diseases, dermatology and severe ulcerative colitis

Constipation

Opioid-induced constipation

Off licence use for intractable diarrhoea under specialist gastroenterology

Darvadstrocel for treating complex perianal fistulas in Crohn’s disease (TA556)

NICE TA556 - Darvadstrocel for treating complex perianal fistulas in Crohn’s disease

Bowel obstruction - reduction of tumour oedema associated with bowel obstruction

Breathlessness

Corticosteroids in palliative care - Anorexia, Adjuvant analgesic, Nausea and vomiting associated with chemotherapy, Obstructive syndromes, Raised intracranial pressure, Spinal cord compression

Nausea and vomiting - raised Intracranial Pressure

Palliative care emergencies - SVC obstruction AND Metastatic spinal cord compression