Medicine Recommendations

Juvenile Idiopathic Arthritis (JIA) in Adult Patients

Rheumatoid arthritis (LSCMMG pathway)

Systemic Juvenile Idiopathic Arthritis (NICE TA238)

NICE TA238 - Tocilizumab for the treatment of systemic juvenile idiopathic arthritis

Tofacitinib for moderately to severely active ulcerative colitis (NICE TA547)

NICE TA547 - Tofacitinib for moderately to severely active ulcerative colitis

MHRA Drug Safety Update, 6 October 2021

Major Adverse Cardiovascular Events MHRA Drug Safety Update

Active ankylosing spondylitis (NICE TA920)

NICE TA920 - Tofacitinib for treating active ankylosing spondylitis

Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs (NICE TA543)

NICE TA 543 - Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs

MHRA Drug Safety Update, 6 October 2021

Major Adverse Cardiovascular Events MHRA Drug Safety Update

Rheumatoid arthritis (LSCMMG pathway)

MHRA Drug Safety Update, 6 October 2021

Major Adverse Cardiovascular Events MHRA Drug Safety Update

Tolcapone as an adjunct to co-beneldopa or co-careldopa in Parkinson's disease with 'end-of-dose' motor fluctuations if another inhibitor of peripheral catechol-O-methyltransferase is inappropriate

Autosomal dominant polycystic kidney disease (NICE TA358)

NICE TA358 - Tolvaptan for treating autosomal dominant polycystic kidney disease

Treatment of hyponatremia in adults, secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH), for patients not requiring chemotherapy.

Migraine prophylaxis

Please note: The MHRA has stated that topiramate is now contraindicated in pregnancy and in women of childbearing potential unless the conditions of a Pregnancy Prevention Programme are fulfilled.

MHRA: Topiramate (Topamax): introduction of new safety measures, including a Pregnancy Prevention Programme

Treating moderate to severe atopic dermatitis - NICE TA814

NICE TA814 - Abrocitinib, tralokinumab or upadacitinib for treating moderate to severe atopic dermatitis

Non-Neurogenic Bowel Disorders, Chronic Constipation or Chronic Faecal Incontinence

Peristeen transanal irrigation system for managing bowel dysfunction (MTG36)

Neurogenic Bowel Dysfunction

Peristeen transanal irrigation system for managing bowel dysfunction (MTG36)

Depressive illness

Vaccination (travel)

N/A

Depressive illness

Acute Gout (as per LSCMMG Guidelines)

Insomnia (short term use)