Prucalopride

Use in women: NICE TA 211 (Prucalopride for the treatment of chronic constipation in women)
Prucalopride is recommended as an option for the treatment of chronic constipation only in women for whom treatment with at least two laxatives from different classes, at the highest tolerated recommended doses for at least 6 months, has failed to provide adequate relief and invasive treatment for constipation is being considered.
If treatment with prucalopride is not effective after 4 weeks, the woman should be re-examined and the benefit of continuing treatment reconsidered.
Prucalopride should only be prescribed by a clinician with experience of treating chronic constipation, who has carefully reviewed the woman’s previous courses of laxative treatments.

Use in men: Prucalopride for the treatment of chronic constipation in men
LSCMMG recommends prucalopride as an option for the treatment of chronic constipation in men for whom treatment with at least two laxatives from different classes, at the highest tolerated recommended doses for at least 6 months, has failed to provide adequate relief and invasive treatment for constipation is being considered.
If treatment with prucalopride is not effective after 4 weeks, the man should be re-examined and the benefit of continuing treatment reconsidered.
Prucalopride should only be prescribed by a clinician with experience of treating chronic constipation, who has carefully reviewed the man’s previous courses of laxative treatments.