Topiramate
Indication
Migraine prophylaxis
Please note: The MHRA has stated that topiramate is now contraindicated in pregnancy and in women of childbearing potential unless the conditions of a Pregnancy Prevention Programme are fulfilled.
Brand:
Nice TA:
Commissioning responsibility:
CCG
PbR excluded:
No
Background
Recommended for Migraine Prophylaxis in line with the Primary Care Adult Headache Management Pathway
Please note: The MHRA has stated that topiramate is now contraindicated in pregnancy and in women of childbearing potential unless the conditions of a Pregnancy Prevention Programme are fulfilled. This follows a review by the MHRA which concluded that the use of topiramate during pregnancy is associated with significant harm to the unborn child. Harms included a higher risk of congenital malformation, low birth weight and a potential increased risk of intellectual disability, autistic spectrum disorder and attention deficit hyperactivity disorder in children of mothers taking topiramate during pregnancy.
Recommendation
LSCMMG Recommendation:
Green
Reason for decision:
Suitable for initiation in primary care